In an article published in BMJ, Zimmerman et al report an observational study of adults living in Alberta, Canada, between April 1997 and March 2009 who were registered with the provincial health registry. Those who developed a kidney stone during this time (n=23 706) were compared with the rest of the population (n=3 065 488) for risk of developing end stage renal disease (ESRD). They reported that one or more stone episodes during the follow-up period was associated with an increased risk of ESRD (adjusted hazard ratio 2.16 (95% CI 1.79 to 2.62)). The number of individuals who developed ESRD in the entire cohort was 5333 (0.2%) compared with 129 (0.5%) in the kidney stone cohort.
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