In a randomised controlled trial published in BJUI (2012), using 1000mg intramuscular testosterone Ho et al report that overall quality of life as well as symptoms of testosterone deficiency syndrome (TDS) were significantly improved at 48 weeks. All patients had a baseline serum testoserone of <12 and moderate or severe symptoms of TDS. The results were assessed using the AMS and SF-15 questionnaires. This good quality study adds to the growing body of evidence from the medical literature supporting the use of testosterone replacement therapy in patients with a low serum testosterone and symptoms of TDS. It did not investigate previously reported beneficial improvements in glucose intolerance and lipid profile.