In an interesting case-control studyby Wright et al published in Cancer (2012) the authors found a 15% reduction in prostate cancer risk in patients circumcised before first sexual intercourse. The study included 1754 prostate cancer cases and 1645 controls. Approximately 17% of all cancers are caused by infection and there is already other epidemiological evidence linking sexually transmitted infection (STI) to prostate cancer. This publication reinforces the causal relationship between STI and prostate cancer.
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