PSA and long term prediction of prostate cancer

4383 men were followed for 28 years in a study Orsted et al from Denmark (Eur Urol 61(2012) 865-874). Patients with a baseline PSA under 1ng/ml had a very low risk of future prostate cancer diagnosis and mortality. Indeed, an editorial suggested that if PSA<2 and age>64, no further screening is required and if age <65 PSA screening may not need to be repeated for 10 years. If PSA=2-4 then a further PSA screen could be left for 2-4 years. A PSA>4 required a detailed examination for prostate cancer.

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