Oxybutynin increases the effectiveness of desmopressin in the treatment of children with nocturnal enuresis

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In an article by Montaldo et al in BJUI (2012) the authors show that treatment of primary monosynaptic nocturnal enuresis (MNE) in children can be improved by combining desmopressin with oxybutynin. Two thirds of children with MNE do not respond fully to desmopressin monotherapy, but among these patients, the addition of oxybutynin increases the response rate. Nocturnal polyuria predicts response to desmopressin, whereas bladder wall thickness on ultrasound and voiding latency predict response to combination therapy with desmopressin and oxybutynin.

104 Responses to Oxybutynin increases the effectiveness of desmopressin in the treatment of children with nocturnal enuresis

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